LDN has emerged as a potential therapeutic option for individuals with Crohn's disease, which is a chronic inflammatory bowel disease that affects the digestive tract. LDN works by modulating the immune system and reducing inflammation in the gut. LDN binds to the opioid receptor and exert anti-inflammatory effects which alleviates symptoms and promotes remission in Crohn's disease. There is growing evidence that suggests that LDN could be a valuable therapy for managing this challenging condition.

Chronic pain refers to persistent or reoccurring pain that lasts for an extended period of time and typically beyond the normal healing time of an injury or illness. It is a complex and multifaceted condition that can significantly impact a person's physical and emotional well-being. It can arise from a variety of conditions including musculoskeletal disorders, nerve damage, autoimmune diseases, infections, or psychological factors such as stress and trauma. LDN is prescribed to alleviate chronic pain and improve pain management.

LDN has shown positive results in the treatment of psoriasis. Psoriasis is a chronic autoimmune skin condition characterised by red scaly patches on the skin. LDN balances the immune system and reduces inflammation which are key factors in development and progression of psoriasis. LDN blocks receptor in the immune system leading to a decrease in pro-inflammatory cytokines and an increase in anti-inflammatory factors. By reducing inflammation LDN can alleviate skin redness, scaling and itching associated with psoriasis.